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A novel post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease <i>GBA-N370S</i> dopamine neurons

2021-07-01

Abstract excerpt

The causes of Parkinson’s disease (PD) likely involve complex interactions between environmental factors and susceptibility genes with variants at the GBA locus encoding the glucocerebrosidase (GCase) enzyme being the strongest common genetic risk factor for PD. To understand GBA -related disease mechanisms, we used a novel multipart-enrichment proteomics and post-translational modification workflow to simultane...

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Literature Corpus work
e0a01e4f-1897-5c9c-9e74-5ee11f59ec66
DOI
10.1101/2021.06.30.450333
Open publication

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A novel post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease <i>GBA-N370S</i> dopamine neuronsDOI 10.1101/2021.06.30.450333
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