Article
Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles.
The Journal of biological chemistry - 12 Feb 2016
Waite Kenrick A, De-La Mota-Peynado Alina, Vontz Gabrielle, Roelofs Jeroen
Abstract excerpt
The proteasome is responsible for the degradation of many cellular proteins. If and how this abundant and normally stable complex is degraded by cells is largely unknown. Here we show that in yeast, upon nitrogen starvation, proteasomes are targeted for vacuolar degradation through autophagy. Using GFP-tagged proteasome subunits, we observed that autophagy of a core particle (CP) subunit depends on the...
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