Article
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.
Human molecular genetics - 15 Sept 2018
Pellegrini Laura, Hauser David N, Li Yan, Mamais Adamantios, Beilina Alexandra, Kumaran Ravindran, Wetzel Andrea, Nixon-Abell Jonathon, Heaton George, Rudenko Iakov, Alkaslasi Mor, Ivanina Natalie, Melrose Heather L, Cookson Mark R, Harvey Kirsten
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) segregate with familial Parkinson's disease (PD) and genetic variation around LRRK2 contributes to risk of sporadic disease. Although knockout (KO) of Lrrk2 or knock-in of pathogenic mutations into the mouse germline does not result in a PD phenotype, several defects have been reported in the kidneys of Lrrk2 KO mice. To understand LRRK2 function in vivo, we used...
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