Article

The CGG triplet repeat binding protein 1 counteracts DNA secondary structure-induced transcription-replication conflicts

2023-03-09

Abstract excerpt

<h4>Summary</h4> Short tracts of trinucleotide repeats with less than 10 repeats are found frequently throughout the genome without any apparent negative impact on DNA replication fork progression or transcription elongation. CGG binding protein 1 (CGGBP1) binds to CGG triplet repeats and has been implicated in multiple cellular processes such as transcription, replication and DNA damage. Here, we show that CGGBP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 877ed7fe-8179-534f-a03d-c0a59df9d1bb
DOI: 10.1101/2023.03.09.531843

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The CGG triplet repeat binding protein 1 counteracts DNA secondary structure-induced transcription-replication conflictsDOI 10.1101/2023.03.09.531843Read

RNA G-quadruplexes: emerging mechanisms in disease.Semantic proximity Read

<i>RFC1</i> AAGGG pentanucleotide repeats form parallel G-quadruplex: structural implications for aberrant molecular cascades in CANVASSemantic proximity Read

CGGBP1--an indispensable protein with ubiquitous cytoprotective functions.Semantic proximity Read

Pathogenic CANVAS (AAGGG) <sub>n</sub> repeats stall DNA replication due to the formation of alternative DNA structuresSemantic proximity Read

Linking Dynamic DNA Secondary Structures to Genome InstabilitySemantic proximity Read

G-quadruplex structural variations in human genome associated with single-nucleotide variations and their impact on gene activity.Semantic proximity Read

Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.Semantic proximity Read

Non-B DNA structures and their contributions to genetic diversity, aging, and disease.Semantic proximity Read

G-quadruplexes in cancer-related gene promoters: from identification to therapeutic targetingSemantic proximity Read

Slipped strand DNA structuresSemantic proximity Read

Dominant Formation of DNA:RNA Hybrid G-Quadruplexes in the Genomes of Living Human and Mouse CellsSemantic proximity Read

G-quadruplexes as pivotal components of <i>cis</i> -regulatory elements in the human genomeSemantic proximity Read