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Tolerating DNA damage by repriming: Gap filling in the spotlight

30 Aug 2024

Abstract excerpt

Timely and accurate DNA replication is critical for safeguarding genome integrity and ensuring cell viability. Yet, this process is challenged by DNA damage blocking the progression of the replication machinery. To counteract replication fork stalling, evolutionary conserved DNA damage tolerance (DDT) mechanisms promote DNA damage bypass and fork movement. One of these mechanisms involves “skipping” DNA damage...

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PMID: 39236419
DOI: 10.1016/j.dnarep.2024.103758

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