Article

Multiomics profiling of human plasma and CSF reveals ATN derived networks and highlights causal links in Alzheimer’s disease

2022-08-08

Abstract excerpt

<h4>INTRODUCTION</h4> This study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the Amyloid/Tau/Neurodegeneration [AT(N)] framework, MCI conversion to AD, and genetic risk for AD. <h4>METHODS</h4> Using the EMIF-AD MBD cohort, we measured 696 proteins in cerebrospinal fluid (n=371), 4001 proteins in plasma (n=972), 611 metabolites in plasma (n=696) an...

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Literature Corpus work: ddd483ba-8d9c-5cad-836f-1ecdae4d841e
DOI: 10.1101/2022.08.05.22278457

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