Article

Mapping the circulating proteome across neurodegeneration: A harmonized, consortium-scale framework for uncovering molecular pathophysiology

2025-12-12

Abstract excerpt

Large-scale plasma proteomics offers unprecedented opportunities to investigate the systemic biology of neurodegeneration, yet technical heterogeneity, site-specific artifacts, and clinical confounding remain major barriers to reproducible discovery. Leveraging data from 13,733 individuals with Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal dementia (FTD), Parkinson’s disease dementia (PDD), am...

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Literature Corpus work: b1873f4d-9c80-5433-af17-1156adcdb6ae
DOI: 10.64898/2025.12.09.693329

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