Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel.

doi:10.1093/eurheartj/ehx144

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Article

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel.

European heart journal - 21 Aug 2017

Ference Brian A, Ginsberg Henry N, Graham Ian, Ray Kausik K, Packard Chris J, Bruckert Eric, Hegele Robert A, Krauss Ronald M, Raal Frederick J, Schunkert Heribert, Watts Gerald F, Borén Jan, Fazio Sergio, Horton Jay D, Masana Luis, Nicholls Stephen J, Nordestgaard Børge G, van de Sluis Bart, Taskinen Marja-Riitta, Tokgözoglu Lale, Landmesser Ulf, Laufs Ulrich, Wiklund Olov, Stock Jane K, Chapman M John, Catapano Alberico L

Abstract excerpt

AIMS: To appraise the clinical and genetic evidence that low-density lipoproteins (LDLs) cause atherosclerotic cardiovascular disease (ASCVD). METHODS AND RESULTS: We assessed whether the association between LDL and ASCVD fulfils the criteria for causality by evaluating the totality of evidence from genetic studies, prospective epidemiologic cohort studies, Mendelian randomization studies, and randomized trials...

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PMID: 28444290
DOI: 10.1093/eurheartj/ehx144
PMCID: PMC5837225

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