Article

A NATUrally Randomized trial Evaluating a vaccine-like strategy to lower LDL by inhibiting PCSK9 on the lifetime risk of major cardiovascular events (NATURE-PCSK9)

2024-07-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Maintaining low levels of low-density lipoproteins (LDL) over time has the potential to substantially reduce the lifetime risk of atherosclerotic cardiovascular disease. However, the optimal timing of lowering LDL to prevent atherosclerotic cardiovascular events is unknown. <h4>Methods</h4> We combined evidence from Mendelian randomization studies and randomized trials to d...

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Literature Corpus work: 3ae71b16-30ad-5755-a20c-9b68e3ae6399
DOI: 10.1101/2024.06.30.24309740

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