Article

Cholesteryl Ester Transfer Protein as a Drug Target for Cardiovascular Disease

2020-09-09

Abstract excerpt

Drug development of cholesteryl ester transfer protein (CETP) inhibition to prevent coronary heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from drug target failure, we compared evidence from clinical trials and Mendelian randomization (MR) results. Findings from meta-analyses of CETP inhibitor trials (≥ 24 weeks follow-up) were used to judge between-compound heterogeneity in tr...

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Literature Corpus work: 3d4cde65-ca74-5bfc-94cc-fa2694dde4fc
DOI: 10.1101/2020.09.07.20189571

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