Article

The functional change of the P2X7R containing the Ala348 to Thr polymorphism is associated to the pathogenesis of gout

2022-09-09

Abstract excerpt

Our previous study has shown that ATP action on P2X7R could be the second signal to induce the onset of gouty arthritis. However, the function changes of SNPs in the P2X7R, which affect the ATP-P2X7R-IL-1β signaling pathway with high uric acid, remained unknown. We aimed to explore the association between the functional change of the P2X7R containing the Ala 348 to Thr polymorphism (rs1718119) and the pathogenesis...

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Literature Corpus work: 32c7b636-e141-5edf-bea1-8b66a41161ac
DOI: 10.21203/rs.3.rs-2026409/v1

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