Article
The presence of the 1068 G>A variant of P2X7 receptors is associated to an increase in IL-1Ra levels, insulin secretion and pancreatic β-cell function but not with glycemic control in type 2 diabetes patients.
Gene - 30 Apr 2018
Uresti-Rivera Edith Elena, García-Jacobo Rocío Edith, Méndez-Cabañas José Alfredo, Gaytan-Medina Laura Elizabeth, Cortez-Espinosa Nancy, Portales-Pérez Diana Patricia, González-Amaro Roberto, Enciso-Moreno José Antonio, García-Hernández Mariana Haydee
Abstract excerpt
It has been reported that an increased function of the P2X7 purinergic receptor is associated with an increase in both insulin sensitivity and secretion. Accordingly, we explored the possible effect of the 1068 G>A polymorphism of the gene P2RX7 on glucose homeostasis and the levels of the anti-inflammatory cytokine IL-1Ra in T2D patients. The presence of the 1068 G>A polymorphism in T2D patients (n = 100) and...
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