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Article

Single nucleotide polymorphisms associated with P2X7R function regulate the onset of gouty arthritis.

PloS one - 1 Jan 2017

Tao Jin-Hui, Cheng Miao, Tang Jiang-Ping, Dai Xiao-Juan, Zhang Yong, Li Xiang-Pei, Liu Qin, Wang Ya-Ling

Abstract excerpt

BACKGROUND: Gout is an inflammatory disease that is caused by the increased production of Interleukin-1β (IL-1β) stimulated by monosodium urate (MSU) crystals. However, some hyperuricemia patients, even gouty patients with tophi in the joints, never experience gout attack, which indicates that pathogenic pathways other than MSU participate in the secretion of IL-1β in the pathogenesis of acute gouty arthritis....

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Share to Adenosine Triphosphate
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Share to Gout, Hyperuricemia, Uric Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperuricemia

Share to Inflammasome and immune disorders

Share to Interleukin-1beta

Share to Polymorphism, Single Nucleotide

Share to Receptors, Purinergic P2X7

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Identifiers

PMID: 28797095
DOI: 10.1371/journal.pone.0181685
PMCID: PMC5552250

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