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Article

Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions.

Journal of psychiatric research - 1 Apr 2010

Roger Sébastien, Mei Zhu-Zhong, Baldwin Jocelyn M, Dong Li, Bradley Helen, Baldwin Stephen A, Surprenant Annmarie, Jiang Lin-Hua

Abstract excerpt

Genetic linkage studies have previously identified many single non-synonymous nucleotide polymorphisms (SNPs) in the human P2RX7 gene in individuals with affective mood disorders. The P2RX7 gene encodes the P2X(7) receptor (P2X(7)R) that operates as an ATP-activated Ca(2+)-permeable cationic channel and induces formation of a large pore, the two functional properties that are critical for the physiological and...

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PMID: 19931869
DOI: 10.1016/j.jpsychires.2009.10.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions.PMID 19931869Read ↗

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