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Article

The functional change of the P2X7R containing the Ala348 to Thr polymorphism is associated with the pathogenesis of gout.

Scientific reports - 5 Apr 2023

Li Man-Yun, Fang Xuan, Ma Yan, Pan Xian-Yang, Dai Xiao-Juan, Li Xiao-Mei, Li Xiao-Ling, Wang Yi-Ping, Tao Jin-Hui, Li Xiang-Pei

Abstract excerpt

Our previous study has shown that ATP action on P2X7R could be the second signal to induce the onset of gouty arthritis. However, the functional changes of P2X7R single nucleotide polymorphisms (SNPs) on the effects of ATP-P2X7R-IL-1β signaling pathway and uric acid remained unknown. We aimed to investigate the association between the functional change of P2X7R containing the Ala348 to Thr polymorphisms...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Purinergic P2X7

Source

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Identifiers

PMID: 37020014
DOI: 10.1038/s41598-023-32365-2
PMCID: PMC10076518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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