Article
Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers.
International journal of molecular sciences - 30 Jul 2014
Caseley Emily A, Muench Stephen P, Roger Sebastien, Mao Hong-Ju, Baldwin Stephen A, Jiang Lin-Hua
Abstract excerpt
P2X receptors are Ca2+-permeable cationic channels in the cell membranes, where they play an important role in mediating a diversity of physiological and pathophysiological functions of extracellular ATP. Mammalian cells express seven P2X receptor genes. Single nucleotide polymorphisms (SNPs) are widespread in the P2RX genes encoding the human P2X receptors, particularly the human P2X7 receptor. This article will...
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