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Article

A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events.

PloS one - 1 Jan 2012

Gidlöf Olof, Smith J Gustav, Melander Olle, Lövkvist Håkan, Hedblad Bo, Engström Gunnar, Nilsson Peter, Carlson Joyce, Berglund Göran, Olsson Sandra, Jood Katarina, Jern Christina, Norrving Bo, Lindgren Arne, Erlinge David

Abstract excerpt

BACKGROUND AND PURPOSE: Extracellular adenosine triphosphate (ATP) regulates inflammatory cells by activation of the P2X(7) receptor. We hypothesized that polymorphisms in P2RX7 influence the risk of ischemic heart disease (IHD), ischemic stroke (IS) and cardiovascular risk factors and tested this hypothesis using genetic association studies. METHODS: Two loss-of-function SNPs in P2RX7 were genotyped in 1244 IHD...

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Share to Adenosine Triphosphate
Share to Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Order

Share to Linkage Disequilibrium

Share to Mutation, Missense

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Share to Receptors, Purinergic P2X7

Source

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Identifiers

PMID: 22662160
DOI: 10.1371/journal.pone.0037491
PMCID: PMC3360776

Genes

CAMKK2
OASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events.PMID 22662160Read ↗

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