Article

The Function Changes of the Ala348to Thr Polymorphism in the P2X7R Closely Related to the Onset of Gout

2022-03-08

Abstract excerpt

Gout is a common disease of inflammatory arthritis caused by hyperuricemia and the deposition of MSU crystals. Our previous study has shown that ATP action on P2X7R could be the second signal to induce the onset of gouty arthritis. However, the biological function changes of SNPs in the P2X7R, which affect the ATP-P2X7R-IL-1β signaling pathway with high uric acid, remained unknown. To further research P2RX7 gene v...

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Literature Corpus work: ed8afed7-db65-5752-b83a-f556d8b6ee1f
DOI: 10.21203/rs.3.rs-1421046/v1

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