Article
Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences.
Nature genetics - 1 Sept 2024
Burren Oliver S, Dhindsa Ryan S, Deevi Sri V V, Wen Sean, Nag Abhishek, Mitchell Jonathan, Hu Fengyuan, Loesch Douglas P, Smith Katherine R, Razdan Neetu, Olsson Henric, Platt Adam, Vitsios Dimitrios, Wu Qiang, Codd Veryan, Nelson Christopher P, Samani Nilesh J, March Ruth E, Wasilewski Sebastian, Carss Keren, Fabre Margarete, Wang Quanli, Pangalos Menelas N, Petrovski Slavé
Abstract excerpt
Telomeres protect chromosome ends from damage and their length is linked with human disease and aging. We developed a joint telomere length metric, combining quantitative PCR and whole-genome sequencing measurements from 462,666 UK Biobank participants. This metric increased SNP heritability, suggesting that it better captures genetic regulation of telomere length. Exome-wide rare-variant and gene-level...
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