Article

Discovery of an IKK2 Site that Allosterically Controls Its Activation

2021-01-27

Abstract excerpt

<h4>ABSTRACT</h4> IκB kinase 2/β (IKK2) is a critical regulator of inflammation which is inducibly activated by a host of stimuli. Aberrant activation of IKK2 is the leading cause of most inflammatory diseases and many associated cancers. Efforts to prevent these diseases by small-molecule inhibitors of IKK2 activity have not been successful. Most inhibitors developed for IKK2 are ATP-competitive, and they are to...

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Literature Corpus work: 3283de9c-744d-50d3-b955-920507a2eb91
DOI: 10.1101/2021.01.27.428502

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