Article
Allosteric inhibition of Aurora-A kinase by a synthetic V <sub>NAR</sub> nanobody
2016-04-02
Abstract excerpt
The vast majority of clinically-approved protein kinase inhibitors target the ATP binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects. Allosteric inhibitors are generally more selective, but are difficult to identify because allosteric binding sites are often unknown or poorly characterized, and there is no clearly preferred approach t...
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Identifiers and source
- Literature Corpus work
- b55e18e9-b668-57a3-99c2-be02e474fb56
- DOI
- 10.1101/046730