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Article

Expression, purification and functional characterization of IkappaB kinase-2 (IKK-2) mutants.

Protein expression and purification - 1 Aug 2010

Mathialagan Sumathy, Poda Gennadiy I, Kurumbail Ravi G, Selness Shaun R, Hall Troii, Reitz Beverly A, Weinberg Robin A, Kishore Nandini, Mbalaviele Gabriel

Abstract excerpt

NF-kappaB signaling plays a pivotal role in a variety of pathological conditions. Because of its central role in the overall NF-kappaB regulation, IKK-2 is a viable target for drug discovery. In order to enable structure-based design of IKK-2 inhibitors, we carried out a rational generation of IK...

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Identifiers

PMID: 20176108
DOI: 10.1016/j.pep.2010.02.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20176108-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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