Article

PI3Kδ is selectively inhibited by roginolisib through stabilizing of the C-terminal helix kα12

2026-01-07

Abstract excerpt

<title>Abstract</title> <p>Phosphoinositide 3-kinases (PI3Ks) are major regulators of cell growth, proliferation and signalling, constituting key therapeutic targets in cancer, inflammation, and other diseases. Individual class I PI3K isoforms control key cellular functions, imposing the need to generate isoform-specific inhibition for therapeutic intervention. Roginolisib is a selective PI3Kδ inhibitor that show...

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Literature Corpus work: 9321d7e0-0576-5639-9637-3f64981bf961
DOI: 10.21203/rs.3.rs-8048396/v1

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