Article

Identification of CK2α’ selective inhibitors by the screening of an allosteric-kinase-inhibitor-like compound library

2024-01-22

Abstract excerpt

Protein Kinase CK2 is a holoenzyme composed of two regulatory subunits (CK2β) and two catalytic subunits (CK2α and CK2α’). CK2 controls several cellular processes including proliferation, inflammation, and cell death. However, CK2α and CK2α’ possess different expression patterns and substrates and therefore impact each of these processes differently. Elevated CK2α participates in the development of cancer, while i...

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Literature Corpus work: e494b2d7-0467-5a66-993f-6c02607caa60
DOI: 10.1101/2024.01.18.576328

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