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Article

NudEL targets dynein to microtubule ends through LIS1.

Nature cell biology - 1 Jul 2005

Li Jun, Lee Wei-Lih, Cooper John A

Abstract excerpt

Dynein is a minus-end-directed microtubule motor with critical roles in mitosis, membrane transport and intracellular transport. Several proteins regulate dynein activity, including dynactin, LIS1 (refs 2, 3) and NudEL (NudE-like). Here, we identify a NUDEL homologue in budding yeast and name it Ndl1. The ndl1delta null mutant shows decreased targeting of dynein to microtubule plus ends, an essential element of...

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Identifiers

PMID: 15965467
DOI: 10.1038/ncb1273
PMCID: PMC1569433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

NudEL targets dynein to microtubule ends through LIS1.PMID 15965467Read ↗

Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kinetochore function.Semantic proximity Read ↗

The CLIP-170 orthologue Bik1p and positioning the mitotic spindle in yeast.Semantic proximity Read ↗

Lis1 relieves cytoplasmic dynein-1 auto-inhibition by acting as a molecular wedgeSemantic proximity Read ↗

Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedgeSemantic proximity Read ↗

Structural Basis for Cytoplasmic Dynein-1 Regulation by Lis1Semantic proximity Read ↗

Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly.Semantic proximity Read ↗

Pac1/LIS1 promotes an uninhibited conformation of dynein that coordinates its localization and activitySemantic proximity Read ↗

Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.Semantic proximity Read ↗

Nde1 Promotes Lis1-Mediated Activation of DyneinSemantic proximity Read ↗

Roles of the Drosophila NudE protein in kinetochore function and centrosome migration.Semantic proximity Read ↗

NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins.Semantic proximity Read ↗

LIS1 controls mitosis and mitotic spindle organization via the LIS1-NDEL1-dynein complex.Semantic proximity Read ↗

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