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Measuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical Implications

26 Apr 2021

Abstract excerpt

The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states...

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PMID: 33902034
DOI: 10.1159/000515289

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