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Article

Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer.

Nature communications - 11 Feb 2023

Malagoli Tagliazucchi Guidantonio, Wiecek Anna J, Withnell Eloise, Secrier Maria

Abstract excerpt

The epithelial to mesenchymal transition (EMT) is a key cellular process underlying cancer progression, with multiple intermediate states whose molecular hallmarks remain poorly characterised. To fill this gap, we present a method to robustly evaluate EMT transformation in individual tumours based on transcriptomic signals. We apply this approach to explore EMT trajectories in 7180 tumours of epithelial origin...

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Identifiers

PMID: 36774358
DOI: 10.1038/s41467-023-36439-7
PMCID: PMC9922305

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