Article

Cellular and structural basis of synthesis of the unique intermediate dehydro-F <sub>420</sub> -0 in mycobacteria

2020-02-28

Abstract excerpt

F 420 is a low-potential redox cofactor used by diverse bacteria and archaea. In mycobacteria, this cofactor has multiple roles, including adaptation to redox stress, cell wall biosynthesis, and activation of the clinical antitubercular prodrugs pretomanid and delamanid. A recent biochemical study proposed a revised biosynthesis pathway for F 420 in mycobacteria; it was suggested that phosphoenolpyruvate served...

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Literature Corpus work: 3220d460-8aa9-55d2-84f0-b5e9eae2fe95
DOI: 10.1101/2020.02.27.968891

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