Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness

10 Apr 2018

Abstract excerpt

Mycolic acids (MAs) have a strategic location within the mycobacterial envelope, deeply influencing its architecture and permeability, and play a determinant role in the pathogenicity of mycobacteria. The fatty acid synthase type II (FAS-II) multienzyme system is involved in their biosynthesis. A combination of pull-downs and proteomics analyses led to the discovery of a mycobacterial protein, HadD, displaying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mycobacterium research and diagnosis
Share to RNA and protein synthesis mechanisms
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29662082
DOI: 10.1038/s41598-018-24380-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitnessPMID 29662082Read ↗

The Mycobacterium Tuberculosis FAS-II Dehydratases and Methyltransferases Define the Specificity of the Mycolic Acid Elongation ComplexesSemantic proximity Read ↗

The Molecular Genetics of Mycolic Acid BiosynthesisSemantic proximity Read ↗

The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis.Semantic proximity Read ↗

Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex.Semantic proximity Read ↗

MmpL3 is the flippase for mycolic acids in mycobacteriaSemantic proximity Read ↗

The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid.Semantic proximity Read ↗

Characterization of a beta-hydroxybutyryl-CoA dehydrogenase from Mycobacterium tuberculosis.Semantic proximity Read ↗

Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.Semantic proximity Read ↗

Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in MycobacteriaSemantic proximity Read ↗

The phenotypic landscape of the mycobacterial cellSemantic proximity Read ↗

Dissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosis.Semantic proximity Read ↗

Genetic and lipidomic identification of tuberculostearic acid as a controller of mycobacterial membrane compartmentalizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.