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Article

Structural and functional studies of phosphoenolpyruvate carboxykinase from Mycobacterium tuberculosis.

PloS one - 1 Jan 2015

Machová Iva, Snášel Jan, Dostál Jiří, Brynda Jiří, Fanfrlík Jindřich, Singh Mahavir, Tarábek Ján, Vaněk Ondřej, Bednárová Lucie, Pichová Iva

Abstract excerpt

Tuberculosis, the second leading infectious disease killer after HIV, remains a top public health priority. The causative agent of tuberculosis, Mycobacterium tuberculosis (Mtb), which can cause both acute and clinically latent infections, reprograms metabolism in response to the host niche. Phosphoenolpyruvate carboxykinase (Pck) is the enzyme at the center of the phosphoenolpyruvate-pyruvate-oxaloacetate node,...

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Identifiers

PMID: 25798914
DOI: 10.1371/journal.pone.0120682
PMCID: PMC4370629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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