Article

Exquisite specificity of Pks13 defines the essentiality of trehalose in mycobacteria

2025-04-03

Abstract excerpt

Mycolic acids (MAs) are the major component of the mycobacterial outer membrane, a key contributor to the intrinsic resistance of mycobacteria to external insults including multiple antibiotics. After being synthesized in the cytoplasm and before reaching the outer membrane, MAs are transported across the inner membrane in the form of an acylated sugar, generally believed to be trehalose monomycolates (TMMs). Whet...

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Literature Corpus work: af2694b5-0412-5094-9734-1c447d82f6a6
DOI: 10.1101/2025.04.03.647003

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