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Unexpected Abundance of Coenzyme F <sub>420</sub> -Dependent Enzymes in <i>Mycobacterium tuberculosis</i> and Other Actinobacteria

31 Jul 2010

Abstract excerpt

Regimens targeting Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), require long courses of treatment and a combination of three or more drugs. An increase in drug-resistant strains of M. tuberculosis demonstrates the need for additional TB-specific drugs. A notable feature of M. tuberculosis is coenzyme F(420), which is distributed sporadically and sparsely among prokaryotes. This...

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PMID: 20675471
DOI: 10.1128/jb.00425-10

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