Cell-type specific analyses in blood and gut identify cis-eQTL matching 140 IBD risk loci and entrectinib as repurposing candidate.

doi:10.1038/s41467-026-76672-4

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Article

Cell-type specific analyses in blood and gut identify cis-eQTL matching 140 IBD risk loci and entrectinib as repurposing candidate.

Nature communications - 1 Sept 2026

Perée Hélène, Petrov Viacheslav A, Tokunaga Yumie, Kvasz Alexander, Farnir Frédéric, Vieujean Sophie, Regimont Sarah, Mni Myriam, Wéry Marie, Azarzar Samira, Jacques Sophie, Fouillien Nicolas, Karim Latifa, Deckers Manon, Detry Emilie, Mayer Alice, Stephan Raafat, Harshman Keith, Mizoro Yasutaka, Reenaers Catherine, Van Kemseke Catherine, Warling Odile, Labille Virginie, Kropp Sophie, Poncin Maxime, Catherine Moreau Anne, Servais Benoit, Loly Jean-Philippe, Coppieters Wouter, Dermitzakis Emmanouil, Louis Edouard, Georges Michel, Takeda Haruko, Rahmouni Souad

Abstract excerpt

Genes whose expression is affected, in a consistent manner, by GWAS-identified risk variants and the disease process, constitute preferred drug targets. We herein combine cis-eQTL analysis in 27 sorted blood cell populations and 43 intestinal cell types identified by single cell RNA-Seq in the ileum, colon and rectum, with information on gene expression in patients, to search for putative drug targets for...

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Topics

Humans
Inflammatory Bowel Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Indazoles

Benzamides

Quantitative Trait Loci

Genome-Wide Association Study

Drug Repositioning

Genetic Predisposition to Disease

NIMA-Related Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 42768013
DOI: 10.1038/s41467-026-76672-4
PMCID: PMC13594155

Genes

NEK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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