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Article

Shared Genetics in Celiac Disease and Inflammatory Bowel Disease Specify a Greater Role for Intestinal Epithelial Cells.

International journal of molecular sciences - 25 Mar 2025

Ribeiro Nathan Vinícius, Anwar Sajid, Withoff Sebo, Jonkers Iris H

Abstract excerpt

The contribution of genetics to the development of gut-related autoimmune diseases such as celiac disease (CeD) and inflammatory bowel diseases (IBDs) is well-established, especially in immune cells, but pinpointing the significance of genetic variants to other cell types is more elusive. Increasing evidence indicates that intestinal epithelial cells are active players in modulating the immune response,...

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Topics

Humans
Celiac Disease
Inflammatory Bowel Diseases
Epithelial Cells
Intestinal Mucosa
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Animals

Source

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Identifiers

PMID: 40243612
DOI: 10.3390/ijms26072982
PMCID: PMC11988521

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