Article

Integrated cell type-specific analysis of blood and gut identifies matching eQTL for 140 IBD risk loci and entrectinib as possible repurposing candidate

2024-10-15

Abstract excerpt

Genes whose expression is affected in a consistent manner by GWAS-identified risk variants and the disease process, constitute preferred drug targets. We herein combine integrated cis-eQTL analysis in 27 blood cell populations and 43 intestinal cell types of the ileum, colon and rectum, and information on gene expression in patients, to search for putative drug targets for inflammatory bowel disease (IBD). We dete...

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Literature Corpus work: d6e2fb9c-6348-51e0-932c-d10a0a68863c
DOI: 10.1101/2024.10.14.24315443

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