Article
Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates.
Nature genetics - 1 Jul 2015
Ottolini Christian S, Newnham Louise, Capalbo Antonio, Natesan Senthilkumar A, Joshi Hrishikesh A, Cimadomo Danilo, Griffin Darren K, Sage Karen, Summers Michael C, Thornhill Alan R, Housworth Elizabeth, Herbert Alex D, Rienzi Laura, Ubaldi Filippo M, Handyside Alan H, Hoffmann Eva R
Abstract excerpt
Crossover recombination reshuffles genes and prevents errors in segregation that lead to extra or missing chromosomes (aneuploidy) in human eggs, a major cause of pregnancy failure and congenital disorders. Here we generate genome-wide maps of crossovers and chromosome segregation patterns by recovering all three products of single female meioses. Genotyping >4 million informative SNPs from 23 complete meioses...
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