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Article

TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues.

The Journal of biological chemistry - 20 Apr 2018

Li Hao-Ru, Chiang Wan-Chin, Chou Po-Chun, Wang Won-Jing, Huang Jie-Rong

Abstract excerpt

Eukaryotic cells contain distinct organelles, but not all of these compartments are enclosed by membranes. Some intrinsically disordered proteins mediate membraneless organelle formation through liquid-liquid phase separation (LLPS). LLPS facilitates many biological functions such as regulating RNA stability and ribonucleoprotein assembly, and disruption of LLPS pathways has been implicated in several diseases....

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Identifiers

PMID: 29511089
DOI: 10.1074/jbc.AC117.001037
PMCID: PMC5912450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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