Article
Toward the Systemic Replacement of Mitochondrial DNA with Somatic Mutations
2024-11-28
Abstract excerpt
The accumulation of lipofuscin, i.e., indigestible intracellular debris, might be the main cause of age-related diseases that we see today. However, without being able to replace mutated mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) that has suffered epigenetic drift, damage, and mutations, we will still eventually succumb to aging. Thus, we must save copies of mitochondrial and nuclear DNA at as young an age a...
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Identifiers and source
- Literature Corpus work
- 31d8263f-3532-5afd-bd7e-e9e059f1f454
- DOI
- 10.20944/preprints202411.1708.v2