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Article

Mitochondrial DNA mutations associated with aging and degenerative diseases.

Experimental gerontology - 1 Jan 2000

Ozawa T

Abstract excerpt

Accumulating evidence has emphasized the role of genetic factors in the development of aging and degenerative diseases. Mitochondrial DNA (mtDNA), that codes for protein subunits essential for the maintenance of mitochondrial ATP synthesis, acquires mutations at a much higher rate than that of nuclear DNA. Recent studies have shown that somatically acquired mutations such as deletions in mtDNA are caused by...

Topics

Aging
Amino Acid Sequence
Animals
Base Sequence
DNA, Mitochondrial
Electron Transport
Female
Humans
Male
Mitochondria
Mitochondrial Myopathies
Molecular Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Pedigree

Source

Identifiers

PMID: 7556507
DOI: 10.1016/0531-5565(94)00057-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7556507-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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