Improving upon nature's somatic mitochondrial DNA therapies.

Abstract excerpt

Mitochondrial DNA (mtDNA) directs key metabolic functions in eukaryotic cells. While a number of mtDNA mutations are known causes of human diseases and age-related dysfunctions, some mtDNA haplotypes are associated with extreme longevity. Despite the mutagenic mitochondrial environment naturally enhancing somatic mtDNA mutation rates, mtDNA remains grossly stable along generations of plant and animal species...

Topics

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• DNA, Mitochondrial
• Gene Conversion
• Gene Transfer Techniques
• Genetic Complementation Test
• Genetic Therapy
• Models, Genetic