Article
Generation of somatic mitochondrial DNA-replaced cells for mitochondrial dysfunction treatment.
Scientific reports - 25 May 2021
Maeda Hideki, Kami Daisuke, Maeda Ryotaro, Shikuma Akira, Gojo Satoshi
Abstract excerpt
Mitochondrial diseases currently have no cure regardless of whether the cause is a nuclear or mitochondrial genome mutation. Mitochondrial dysfunction notably affects a wide range of disorders in aged individuals, including neurodegenerative diseases, cancers, and even senescence. Here, we present a procedure to generate mitochondrial DNA-replaced somatic cells with a combination of a temporal reduction in...
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