Article
An update on the mitochondrial-DNA mutation hypothesis of cell aging.
Mutation research - 1 Sept 1992
Miquel J
Abstract excerpt
Our electron microscopic study of aging insects and mammals suggests that metazoan senescence is linked to a gradual process of mitochondrial breakdown (and lipofuscin accumulation) in fixed postmitotic cells. This led us to propose in the early 1980s an oxyradical-mitochondrial DNA damage hypothesis, according to which metazoan aging may be caused by mutation, inactivation or loss of the mitochondrial genome...
Topics
- Animals
- Biological Evolution
- Cellular Senescence
- DNA Damage
- DNA, Mitochondrial
- Genome
- Humans
- Insecta
- Mammals
- Mitochondria
- Models, Biological
- Mutation