Article
Analysis of α-Synuclein in Exosomes.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Tsunemi Taiji, Ishiguro Yuta, Yoroisaka Asako, Hattori Nobutaka
Abstract excerpt
Alpha synuclein (α-Syn), a presynaptic protein with unknown function, is accumulated in Lewy bodies/neurites that are one of the hallmark pathologies of Parkinson's disease (PD). Missense or multiplication mutations in SNCA, which codes α-Syn, result in a genetic form of PD, further indicating the involvement of α-Syn in PD pathogenesis. Recent pathological and experimental studies suggest that α-Syn possesses a...
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