Article
Parkinson's disease-linked DNAJC13 mutation aggravates alpha-synuclein-induced neurotoxicity through perturbation of endosomal trafficking.
Human molecular genetics - 1 Mar 2018
Yoshida Shun, Hasegawa Takafumi, Suzuki Mari, Sugeno Naoto, Kobayashi Junpei, Ueyama Morio, Fukuda Mitsunori, Ido-Fujibayashi Akemi, Sekiguchi Kiyotoshi, Ezura Michinori, Kikuchi Akio, Baba Toru, Takeda Atsushi, Mochizuki Hideki, Nagai Yoshitaka, Aoki Masashi
Abstract excerpt
Mutations in DNAJC13 gene have been linked to familial form of Parkinson's disease (PD) with Lewy pathology. DNAJC13 is an endosome-related protein and believed to regulate endosomal membrane trafficking. However, the mechanistic link between DNAJC13 mutation and α-synuclein (αSYN) pathology toward neurodegeneration remains poorly understood. In this study, we showed that PD-linked N855S-mutant DNAJC13 caused...
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