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Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons

2020-08-11

Abstract excerpt

The piRNA pathway safeguards genomic integrity by silencing transposable elements in the germline. While Piwi is the central piRNA factor, others including Asterix/Gtsf1 have also been demonstrated to be critical for effective silencing. Here, using eCLIP with a custom informatic pipeline, we show that Asterix/Gtsf1 specifically binds tRNAs in cellular contexts. We determined the structure of mouse Gtsf1 by NMR sp...

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Identifiers and source

Literature Corpus work
31cbb136-2856-51fe-ba50-e075f2fa9f48
DOI
10.1101/2020.08.11.246769
Open publication

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Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposonsDOI 10.1101/2020.08.11.246769
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