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Structure and functional mapping of the KRAB-KAP1 repressor complex

2022-03-17

Abstract excerpt

Transposable elements (TEs) are a genetic reservoir from which new genes and regulatory elements can emerge. Expression of TEs can be pathogenic, however, and is tightly regulated. KRAB domain-containing zinc finger proteins (KRAB-ZFPs) recruit co-repressor KRAB-associated protein 1 (KAP1/TRIM28) to regulate many TEs but how KRAB-ZFPs and KAP1 interact remains unclear. Here, we report the crystal structure of the...

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Literature Corpus work
a20a4d9e-cc91-5d61-b128-522e06a5b13d
DOI
10.1101/2022.03.17.484746
Open publication

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Structure and functional mapping of the KRAB-KAP1 repressor complexDOI 10.1101/2022.03.17.484746
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