Article

Utilizing nullomers in cell-free RNA for early cancer detection

2023-06-16

Abstract excerpt

Early detection of cancer can significantly improve patient outcomes; however, sensitive and highly specific biomarkers for cancer detection are currently missing. Nullomers are short sequences that are absent from the human genome but can resurface due to somatic mutations in cancer. We examine over 10,000 whole exome sequencing matched tumor-normal samples to characterize nullomer resurfacing across exonic regio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 31bb1b5a-381d-5306-a328-14e9d2368c47
DOI: 10.1101/2023.06.10.23291228

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Utilizing nullomers in cell-free RNA for early cancer detectionDOI 10.1101/2023.06.10.23291228Read

Utilizing nullomers in cell-free RNA for early cancer detection.Semantic proximity Read

neomerDB: a comprehensive database of neomer biomarkers in cancer.Semantic proximity Read

Detecting known neoepitopes, gene fusions, transposable elements, and circular RNAs in cell-free RNASemantic proximity Read

Peptide absent sequences emerging in human cancers.Semantic proximity Read

Leveraging sequences missing from the human genome to diagnose cancerSemantic proximity Read

Phenotypic POLE Variant Classification Identifies Patients Who May Have Favorable Prognosis and Benefit from Immunotherapy.Semantic proximity Read

Absent from DNA and protein: genomic characterization of nullomers and nullpeptides across functional categories and evolution.Semantic proximity Read

POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status.Semantic proximity Read

Nullomers: really a matter of natural selection?Semantic proximity Read

Evidence for negative selection against somatic mutations in fibroblasts with high N-ethyl-N-nitrosourea-induced mutation loadSemantic proximity Read

Comprehensive Pan-Cancer Mutation Density Patterns in Enhancer RNA.Semantic proximity Read

Two main mutational processes operate in the absence of DNA mismatch repair.Semantic proximity Read