Article
Peptide absent sequences emerging in human cancers.
European journal of cancer (Oxford, England : 1990) - 1 Jan 2024
Tsiatsianis Georgios Christos, Chan Candace S Y, Mouratidis Ioannis, Chantzi Nikol, Tsiatsiani Anna Maria, Yee Nelson S, Zaravinos Apostolos, Kantere Verena, Georgakopoulos-Soares Ilias
Abstract excerpt
Early diagnosis of cancer can significantly improve survival of cancer patients; however sensitive and highly specific biomarkers for cancer detection are currently lacking for most cancer types. Nullpeptides are short peptides that are absent from the human proteome. Here, we examined the emergence of nullpeptides during cancer development. We analyzed 3,600,964 somatic mutations across 10,064 whole exome...
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