Article

Leveraging sequences missing from the human genome to diagnose cancer

2021-08-17

Abstract excerpt

Cancer diagnosis using cell-free DNA (cfDNA) has potential to improve treatment and survival but has several technical limitations. Here, we show that tumor-associated mutations create neomers, DNA sequences 13-17 nucleotides in length that are predominantly absent from genomes of healthy individuals, that can accurately detect cancer, including early stages, and distinguish subtypes and features. Using a neomer-b...

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Literature Corpus work: 589cfdfc-e5bb-51b3-8f52-25462128856b
DOI: 10.1101/2021.08.15.21261805

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