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Article

Utilizing nullomers in cell-free RNA for early cancer detection.

Cancer gene therapy - 1 Jun 2024

Montgomery Austin, Tsiatsianis Georgios Christos, Mouratidis Ioannis, Chan Candace S Y, Athanasiou Maria, Papanastasiou Anastasios D, Kantere Verena, Syrigos Nikos, Vathiotis Ioannis, Syrigos Konstantinos, Yee Nelson S, Georgakopoulos-Soares Ilias

Abstract excerpt

Early detection of cancer can significantly improve patient outcomes; however, sensitive and highly specific biomarkers for cancer detection are currently missing. Nullomers are the shortest sequences that are absent from the human genome but can emerge due to somatic mutations in cancer. We examine over 10,000 whole exome sequencing matched tumor-normal samples to characterize nullomer emergence across exonic...

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Identifiers

PMID: 38351138
DOI: 10.1038/s41417-024-00741-3
PMCID: PMC11192629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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